Cryobiosystem Research Center
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Division of Cell Reproduction Biology

[sy.portrait] Yasushi SAITOH
Specialty:Molecular Biology and Cell Biology
Research Interests:
Structure-Function relationship in higher eukaryotic chromosome.
DNA replication and chromatin structure.
Recent Publications:
2006 3 Matsukawa, K.; Ogata, M.; Hikage, T.; Minami, H.; Shimotai, Y.; Saitoh, Y.; Yamashita, T.; Ouchi, A.; Tsutsumi, R.; Fujioka, T. and Tsutsumi, K. (2006)
Antiproliferative activity of root extract from gentian plant (Gentiana triflora) on cultured and implanted tumor cells.
Biosci. Biotech. Biochem., in press. (Summary
2 Shimotai, Y.; Minami, H; Saitoh, Y.; Onodera, Y.; Mishima, Y.; Kelm Jr. R. J. and Tsutsumi, K.(2006)
A binding site for Pura and Purb is structurally unstable and is required for replication in vivo from the rat aldolase B origin.
Biochem, Biophys. Res. Commun., 340: 517-525. (published online December 20, 2005)  (Summary
1 Takahashi, M.; Hikage, T.; Yamashita, T.; Saitoh, Y.; Endou, M. and Tsutsumi, K. (2006)
Stress-Related Proteins Are Specifically Expressed under Non-Stress Conditions in the Overwinter Buds of the Gentian Plant Gentiana triflora.
Breeding Science, 56:39-46. (Summary
2003 1 Wang, Y.;Saitoh, Y.; Sato, T.; Hidaka, S. and Tsutsumi, K.(2003)
Comparison of plastid DNA replication in different cells and tissues of the rice plant.
Plant Mol. Biol. 52(4): 905-913. (Summary
2002 3 Wang, Y.; Saitoh, Y.; Hidaka, S.; Sato, T. and Tsutsumi, K.(2002)
Replication of plastid DNA.
Recent Res. Devel. Plant Biol. 2: 33-48. (Summary
2 Saitoh, Y.; Miyagi, S.; Ariga, H. and Tsutsumi, K.(2002)
Functional domains involved in the interaction between Orc1 and transcriptional repressor AlF-C that bind to an origin/promotor of the rat aldlase B gene.
Nucleic Acids Res., 30: 5205-5212. (Summary
1 Wang, Y.; Tamura, K.; Saitoh, Y.; Sato, T.; Hidaka, S. and Tsutsumi, K.(2002)
Mapping major replication origins on the rice plastid DNA.
Plant Biotech., 19: 27-35.
2001 2 Miyagi, S.; Zhao, Y.; Saitoh, Y.; Tamai, K. and Tsutsumi, K.(2001)
Replication of the rat aldolase B locus differs between aldolase B-expressing and non-expressing cells.
FEBS Lett., 505: 332-336. (Summary
1 Yabuki, T.; Miyagi, S.; Ueda, H.; Saitoh, Y. and Tsutsumi, K.(2001)
A novel growth-related nuclear protein binds and inhibits rat aldolase B gene promoter.
Gene, 264: 123-129. (Summary
2000 2 Miyagi, S.; Zhao, Y.; Saitoh, Y. and Tsutsumi, K.(2000)
An overlapping set of DNA elements in the rat aldolase B gene origin/promoter regulates transcription and autonomous replication.
Biochem. Biophys. Res. Commun., 278: 760-765.
1 Saitoh, Y.; Miyamoto, N.; Okada, T.; Gondo, Y.; Showguchi-Miyata, J.; Hadano, S. and Ikeda, J.-E.(2000)
The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.
Genomics, 67: 291-300.

2004 1 Tsutsumi, K.;Takahashi, M.; Hikage, T.;Yamashita, T.; Saitoh, Y. and Endou, M.(2004)
Identification of Proteins Enriched in The Overwinter Buds of The Gentian Plant: Their Possible Involvement in Cold Tolerance.
7th International Plant Cold Hardiness Seminar. (2004/7/10-15, Sapporo, Japan.)
2001 2 Saitoh, Y.; Saitoh, M.; Ariga, H. and Tsutsumi, K.(2001)
A novel hnRNP family protein AlF-C interact with Orc1 and down-regulates transcription.
3R Symposium. Abstract book: p.87. (2001/11/6-9, 三木)
1 Saitoh, Y.; Miyamoto, N.; Okada, T.; Gondo, Y.; Showguchi-Miyata, J.; Hadano, S. and Ikeda, J.-E.(2000)
A tandem repetitive sequence RS447 human megasatellite encodes a novel deubiquitinating enzyme with functional promotor.
Human Genome Meeting 2000. Programe and Abstract book: p59 (poster no:219). (2000/4/9-12, Vancouver, Canada)
1999 3 Saitoh, Y.; Zhao, Y.; Miyagi, S.; Ariga, H. and Tsutsumi, K.(1999)
DNA sequence required for higher eukaryotic DNA replication origin and its associating protein complex.
2nd 3R (Replication, Recombination and Repair) Symposium. (1999/11/16-19, Miki, Japan.)
2 Gondo, Y.; Saitoh, Y.; Hadano, S.; Okada, T.; Okada, Y.; Yanagisawa, Y.; Miyamoto, N. and Ikeda, J.-E.(1999)
Isolation and expression of hypervariable human megasatellite DNA RS447 on 4p15 encoding a novel deubiquitinating enzyme.
HUGO Human Genome Meeting: HGM '99. 084. (1999/3/27-30, Brisbane, Australia.)
1 Gondo, Y.; Okada, T.; Saitoh, Y.; Okada, Y. and Ikeda, J.-E.(1999)
Hypervariability of the copy number of human megasatellite DNA RS447 and illegitimate recombination models.
Keystone Symposia on Molecular and Cellular Biology Molecular Mechanisms in DNA Replication and Recombination. 319. (1999/2/16-22, Taos, New Mexico, USA)

2000 1 Saitoh Y, Miyamoto N, Okada T, Gondo Y, Showguchi-Miyata J, Hadano S and Ikeda J.-E.(2000)
2nd Best Poster Prize. (Human Genome Meeting Poster Competition)

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