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Cryobiosystem Research Center |
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| >Tsutsumi |
Division of Cell Reproduction Biology
![[tk.portrait]](1tk.JPG) |
Ken-ichi TSUTSUMI |
| Specialty：Molecular and Cell Genetics | |
| Research Interests： Mechanisms that integrate regulatory pathways involved in DNA replication and transcription in animal cell differentiation. Regulation of cell duplication and gene expressioin in plant meristem. | |
| ○Journal | ||
|---|---|---|
| 2006 | 4 | Yoshino, M.; Nagamatsu, A.; Tsutsumi, K. and Kanazawa, A. （2006） The regulatory function of the upstream sequence of the?β-conglycininα-subunit gene in seed-specific transcription is associated with the presence of RY sequence. Genes & Genetic Systems, in press. （Summary） |
| 3 | Matsukawa, K.; Ogata, M.; Hikage, T.; Minami, H.; Shimotai, Y.; Saitoh, Y.; Yamashita, T.; Ouchi, A.; Tsutsumi, R.; Fujioka, T. and Tsutsumi, K. （2006） Antiproliferative activity of root extract from gentian plant (Gentiana triflora) on cultured and implanted tumor cells. Biosci. Biotech. Biochem., in press. （Summary） | |
| 2 | Shimotai, Y.; Minami, H; Saitoh, Y.; Onodera, Y.; Mishima, Y.; Kelm Jr. R. J. and Tsutsumi, K.（2006） A binding site for Pura and Purb is structurally unstable and is required for replication in vivo from the rat aldolase B origin. Biochem, Biophys. Res. Commun., 340: 517-525. （published online December 20, 2005） （Summary） | |
| 1 | Takahashi, M.; Hikage, T.; Yamashita, T.; Saitoh, Y.; Endou, M. and Tsutsumi, K. （2006） Stress-Related Proteins Are Specifically Expressed under Non-Stress Conditions in the Overwinter Buds of the Gentian Plant Gentiana triflora. Breeding Science, 56:39-46. （Summary） | |
| 2003 | 2 | Itagaki, T.; Tsumagari, N.; Tsutsumi, K. and Chinone, S.（2003） Discrimination of three amphistome species by PCR-RFLP based on rDNA ITS2 markers. J. Vet. Med. Sci., 65: 931-933. |
| 1 | Wang, Y.;Saitoh, Y.; Sato, T.; Hidaka, S. and Tsutsumi, K.（2003） Comparison of plastid DNA replication in different cells and tissues of the rice plant. Plant Mol. Biol. 52(4): 905-913. （Summary） | |
| 2002 | 4 | Yoshino, M.; Kanazawa, A.; Tsutsumi, K.; Nakamura, I.; Takahashi, K. and Shimamoto Y.（2002） Structural Variation Around the Gene Encoding the α Subunit of Soybean β-Conglycinin and Correlation with the Expression of the α Subunit. Breeding Science, 52: 285-292. （Summary） |
| 3 | Wang, Y.; Saitoh, Y.; Hidaka, S.; Sato, T. and Tsutsumi, K.（2002） Replication of plastid DNA. Recent Res. Devel. Plant Biol. 2: 33-48. （Summary） | |
| 2 | Saitoh, Y.; Miyagi, S.; Ariga, H. and Tsutsumi, K.（2002） Functional domains involved in the interaction between Orc1 and transcriptional repressor AlF-C that bind to an origin/promotor of the rat aldlase B gene. Nucleic Acids Res., 30: 5205-5212. （Summary） | |
| 1 | Wang, Y.; Tamura, K.; Saitoh, Y.; Sato, T.; Hidaka, S. and Tsutsumi, K.（2002） Mapping major replication origins on the rice plastid DNA. Plant Biotech., 19: 27-35. | |
| 2001 | 5 | Itagaki, T,; Honnami, M.; Ito, D.; Ito, K.; Tsutsumi, K.; Shibahara, T. and Noda, Y.（2001） Mitochondrial DNA polymorphism of a triploid form of Fasciola in Japan. J. Helminthol., 75(2): 193-196. |
| 4 | Yoshino, M.; Kanazawa, A.; Tsutsumi, K.; Nakamura, I. and Shimamoto, Y.（2001） Structure and characterization of the gene encoding a subunit of soybean β-conglycinin. Genes Genet. Syst., 76: 99-105. （Summary） | |
| 3 | Wang, K.-J.; Takahata, Y.; Ito, K.; Zhao, Y.; Tsutsumi, K. and Kaizuma, N.（2001） Genetic characterization of a novel soybean kunitz trypsin inhibitor. Breeding Science, 51: 185-190. （Summary） | |
| 2 | Miyagi, S.; Zhao, Y.; Saitoh, Y.; Tamai, K. and Tsutsumi, K.（2001） Replication of the rat aldolase B locus differs between aldolase B-expressing and non-expressing cells. FEBS Lett., 505: 332-336. （Summary） | |
| 1 | Yabuki, T.; Miyagi, S.; Ueda, H.; Saitoh, Y. and Tsutsumi, K.（2001） A novel growth-related nuclear protein binds and inhibits rat aldolase B gene promoter. Gene, 264: 123-129. （Summary） | |
| 2000 | 1 | Miyagi, S.; Zhao, Y.; Saitoh, Y. and Tsutsumi, K.（2000） An overlapping set of DNA elements ina the rat aldolase B gene origin/promoter regulates transcription and autonomous replication. Biochem. Biophys. Res. Commun., 278: 760-765. |
| 1999 | 2 | Ito, K.; Kusano, T. and Tsutsumi, K.（1999） A cold-inducible bZIP protein gene in radish root regulated by calcium- and cycloheximide-mediated signals. Plant Sci., 142: 57-65. |
| 1 | Nakamura, H.; Tokairin, Y.; Hidaka, S.; Ejiri, S. and Tsutsumi, K.（1999） Structural variations of the aldolase gene region in different rice cultivars. Breeding Sci., 49: 33-37. | |
| 1998 | 5 | Terui, Y.; Tsutsumi, K.; Kidou, S.; Sawazaki, T.; Kuroiwa, Y.; Yamaki, M. and Ejiri, S.（1998） A novel variant of translation elongation factor-1β: isolation and characterization of the rice gene encoding EF-1β2. Biochim. Biophys., Acta 1442: 369-372. |
| 4 | Itagaki, T. and Tsutsumi, K.（1998） Triploid form of Fasciola in Japan: genetic relationships between Fasciola hepatica and Fasciola gigantica determined by ITS-2 sequence of nuclear rDNA. Int. J. Parasitol., 28: 777-781. | |
| 3 | Itagaki, T.; Tsutsumi, K.; Ito, K. and Tsutsumi, Y.（1998） Taxonomic status of the Japanese triploid forms of Fasciolo : Comparison of mitochondrial ND1 and COI sequences with F. hepatica and F. gigantica. J. Parasitol., 84: 445-448. | |
| 2 | Ikeda, K.; Inoue, S.; Orimo, A.; Tsutsumi, K. and Muramatsu, M.（1998） Promoter analysis of mouse estrogen-responsive finger protein (efp) gene: mouse efp promoter contains an E-box that is also conserved in human. Gene, 216: 155-162. | |
| 1 | Tsutsumi, K. and Zhao, Y.（1998） Initiation of DNA replication at the rat aldolase B locus - an overlapping set of DNA elements regulates transcription and replication? - In: Gene Therapy and Molecular Biology: from molecular mechanisms to clinical applications (Boulikas, T. Ed.), vol.1:pp 599-608. | |
| 1997 | 5 | Nakamura, H.; Tokairin, Y. Tamayama, A.; Kon, S.; Hidaka, S.; Ejiri, S. and Tsutsumi, K.（1997） Cell type- and positionally specific regulation of the aldolase P gene expression in rice seedlings. Biosci. Biotech. Biochem., 61: 256-262. |
| 4 | Ikeda, K.; Tsutsumi, K.; Kimura, S.; Ejiri, S.; Takahashi, J. and Yasuda, Y.（1997） Molecular cloning of a bovine minisatellite DNA homologous to mouse minisatellite. Anim. Sci. Technol., 68: 293-296. | |
| 3 | Kim, S.-Y.; Takahashi, J.; Tsutsumi, K. and Yasuda, Y.（1997） Function of the myogenin gene promoter in the muscular dystrophic transgenic dy/dy mouse. J. Rep. Dev., 43: 39-46. | |
| 2 | Zhao, Y.; Miyagi, S.; Kikawada, T. and Tsutsumi, K.（1997） Sequencerequirement for replication initiation at the rat aldolase B locus implicated in its functional correlation with transcriptional regulation. Biochem. Biophys. Res. Commun., 237: 707-713. | |
| 1 | Ikeda, K.; Inoue, S.; Orimo, A.; Sano, M.; Watanabe, T.; Tsutsumi, K. and Muramatsu, M.（1997） Multiple regulatory elements and binding proteins of the 5'-flanking region of the human estrogen-responsive finger protein (efp) gene. Biochem. Biophys. Res. Commun., 236: 765-771. | |
| 1996 | 1 | Nakamura, H.; Satoh, W.; Hidaka, S.; Kagaya, Y.; Ejiri, S. and Tsutsumi, K.（1996） Genomic structure of the rice aldolase isozyme C-1 gene and its regulation through a protein kinase-phosphatase pathway. Plant Mol. Biol., 30: 381-385. |
| ○Presentation | ||
|---|---|---|
| 2004 | 1 | Tsutsumi, K.;Takahashi, M.; Hikage, T.;Yamashita, T.; Saitoh, Y. and Endou, M.（2004） Identification of Proteins Enriched in The Overwinter Buds of The Gentian Plant: Their Possible Involvement in Cold Tolerance. 7th International Plant Cold Hardiness Seminar. （2004/7/10-15, Sapporo, Japan.） |
| 2003 | 1 | Tsutsumi, K.（2003） Transcription factors implicated in switching from transcription to replication. XIIth Inteernational congress on genes, gene families and isozymes. （2003/7/19-24, Berlin-Dahlem, Germany.） |
| 2001 | 1 | Saitoh, Y.; Saitoh, M.; Ariga, H. and Tsutsumi, K.（2001） A novel hnRNP family protein AlF-C interact with Orc1 and down-regulates transcription. 3R Symposium. Abstract book: p.87. （2001/11/6-9, Miki, Japan.） |
| 1999 | 1 | Saitoh, Y.; Zhao, Y.; Miyagi, S.; Ariga, H. and Tsutsumi, K.（1999） DNA sequence required for higher eukaryotic DNA replication origin and its associating protein complex. 2nd 3R (Replication, Recombination and Repair) Symposium. （1999/11/16-19, Miki, Japan.） |
| 1997 | 4 | Miyagi, S.; Kikawada, T.; Zhao, Y. and Tsutsumi, K.（1997） Structural and functional analysis of initiation region of replication at the rat aldolase B locus. Workshop on DNA Replication and Chromosome Partition, Kazusa Academia Park, Japan. |
| 3 | Ito, K.; Kikawada, T.; Miyagi, S.; Zhao, Y. and Tsutsumi, K.（1997） Chromosomal state of an eukaryotic replication origin that contains cell type-specific transcription promoter. International Conference on Gene Therapy and Molecular Biology. （1997/8/16-24, Heraklion, Greece） | |
| 2 | Tsutsumi, K.（1997） Structure and function of a replication origin emcompassing a transcription promoter. International Conference on Gene Therapy and Molecular Biology. （1997/8/16-24, Heraklion, Greece） | |
| 1 | Honnami, M.; Itagaki, T.; Tsutsumi, K. and Ito, K.（1997） Mitochondrial DNA polymorphism in triploid Japanese Fasciola sp. Parasitology International. 46(Suppl.): 76. （1997/4/3-5, Chiba, Japan.） | |